Research

Tackling RNA's Biggest Challenges Through Collaborative Research

The NSW RNA Research and Training Network research is aligned within three priority Themes addressing key challenges in the RNA industry

Delivery Systems Theme

This Theme is focused on the development of methods for delivery of RNA therapeutics to difficult-to-reach targets, with more favourable safety, immunogenicity and targeting than current technologies. It includes novel RNA chemistry, targeted delivery systems based on peptides, antibody and carbohydrate ligands as well as improved formulation, manufacturing and analytical testing.

Initial project (2025-2027)

Universal Intranasal Influenza Treatment Using Antiviral siRNA

Key initial project participants

Macquarie University and The Woolcock Institute of Medical Research
UNSW Sydney & The Kirby Institute
Centenary Institute

RNA Science Theme

This Theme is focused on providing efficient ways to design, test and optimise RNA therapeutics, including:

Bioinformatics, RNA design & interactions
Coding and non-coding RNA in therapeutics
Tracking RNA-immune system interactions
RNA in brain function and diseases

Initial project (2025-2027)

Innovative design and synthesis approaches for therapeutic coding and noncoding RNA

Key initial project participants

Australian National University and the Shine-Dalgarno Centre for RNA Innovation
Children’s Medical Research Institute
UNSW SydneyUniversity of Sydney

Immune System and Brain Theme

This Theme supports research projects and activities relating to RNA therapeutics targeting the immune systems and the brain with focus on:

In vivo CAR-T
Vaccine development including cancer vaccines
Brain cancers
Neurological and neurodegenerative conditions including Alzheimer’s

Initial project (2025-2027)

In vivo generation of Chimeric Antigen Receptor T (CAR T) cells for the treatment of brain cancer

Key initial project participants

UNSW & Children’s Cancer Institute
Macquarie University & The Woolcock Institute of Medical Research